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Baseline characteristic
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NS, mean ± SD
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TS, mean ± SD
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All patients
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GHD subseta
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All patients
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GHD subseta
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N, Sex (male:female)
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N = 30 (24:6)
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n = 8 (7:1)
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N = 294 (0:294)
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n = 21
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Age, years (range)
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8.39 ± 3.45 (2.38–14.29)
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8.97 ± 4.19 (2.38–14.04)
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7.81 ± 3.22 (0.51–15.23)
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8.22 ± 3.21 (3.08–14.45)
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HSDS
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−2.64 ± 0.96
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−2.61 ± 0.81
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−2.67 ± 0.88
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−2.84 ± 0.53
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HSDS (Ranke)b [7, 19]
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−0.46 ± 0.89
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−0.43 ± 0.85
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0.30 ± 0.99
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−0.07 ± 0.67
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HSDS (Westerlaken) [21]
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NA
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NA
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−0.20 ± 1.01
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−0.53 ± 0.71
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HSDS (Cabrol) [20]
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NA
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NA
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−0.05 ± 1.03
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−0.39 ± 0.70
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Target HSDS
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−0.43 ± 0.83
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−0.81 ± 0.75 (n = 6)
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−0.24 ± 1.02
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−0.56 ± 0.89
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TH-corrected HSDSc
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−2.19 ± 1.14
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−1.70 ± 1.19 (n = 6)
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−2.46 ± 1.16
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−2.27 ± 1.10
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Bone age, years
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6.92 ± 3.58
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6.96 ± 4.92 (n = 6)
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6.72 ± 3.03
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7.56 ± 3.12 (n = 12)
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Bone age – chronological age
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−1.61 ± 1.22
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−2.08 ± 1.17 (n = 6)
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−1.31 ± 1.12
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−1.49 ± 1.07 (n = 12)
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Father’s height (cm)
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176.19 ± 7.38
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173.78 ± 6.71 (n = 6)
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176.94 ± 7.89
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172.85 ± 8.05
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Mother’s height (cm)
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161.53 ± 8.49
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158.08 ± 4.96 (n = 6)
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163.57 ± 6.96
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162.18 ± 6.93
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IGF-I SDS
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−1.42 ± 1.45 (n = 19)
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−2.52 ± 1.27 (n = 5)
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−0.89 ± 1.51 (n = 147)
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−1.21 ± 1.28 (n = 11)
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GHD Growth hormone deficiency, HSDS Height standard deviation score, NA Not applicable, TH Target height, SDS Standard deviation score
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aGHD defined by GH peak < 10 μg/L
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bHSDS (Ranke) NS vs TS mean difference –0.76 (95% confidence interval –1.13, –0.39); P < 0.001
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cTH-corrected HSDS refers to attainment of genetic height potential, i.e., parental-height-corrected HSDS – defined as HSDS minus target HSDS, during 4 years of GH treatment
