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| |
GH alone
|
GH + Anastrazole
|
P
|
|---|
|
N
|
12
|
12
| |
|
GH dosage (mg/k.d)
|
0.073 ± 0.09
|
0.076 ± 0.01
|
NS
|
|
Duration of GH administration (mo)
|
11.5 ± 5
|
19 ± 5.9
|
0.02
|
|
Age at end of GH (yrs)
|
16.2 ± 1.1
|
16.8 ± 0.7
|
0.08
|
|
Mean IGF1 (SDS)
|
0.55 ± 0.3
|
0.65 ± 0.6
|
NS
|
|
Delta IGF1 (SDS)*
|
1.02 ± 0.3
|
0.97 ± 0.5
|
NS
|
|
Predicted height**
| | | |
|
cm
|
158.2 ± 2.9
|
157.9 ± 3.8
|
NS
|
|
SDS
|
- 2.84 ± 0.5
|
- 2.9 ± 0.6
|
NS
|
|
Final height
| | | |
|
cm
|
164.2 ± 5.6
|
168.4 ± 2.6
|
0.02
|
|
SDS
|
- 1.8 ± 0.9
|
- 1.1 ± 0.4
|
0.02
|
|
Growth velocity Year 1 (cm/yr)
|
4.9 ± 4
|
6.7 ± 2.8
|
0.18
|
|
Growth velocity Year 2 (cm/yr)
|
1.2 ± 0.5
|
3.6 ± 2.7
|
0.008
|
|
Height increase from GH onset (HtG1) (cm)
|
7.8 ± 5
|
12.7 ± 5.6
|
0.02
|
|
Height gain vs PAH (HtG2) (cm)
|
5.9 ± 4.5
|
10.5 ± 5.2
|
0.02
|
- Values are expressed as mean ± SD.
- *Mean IGF1 during GH-IGF1 at onset of GH.
- **see Methods/Calculation.
