A randomized pilot trial of growth hormone with anastrozole versus growth hormone alone, starting at the very end of puberty in adolescents with idiopathic short stature

Table 2 Characteristics of the growth curve of the 24 adolescent males at onset of rhGH or rhGH + Anastrazole administration

	GH alone	GH + Anastrazole	Historical controls
N	12	12	17
Age at take-off of growth (yrs)	12.3 ± 1.2	12.3 ± 0.9	12.2 ± 1.5
Height at take-off of growth
cm	139.7 ± 4	139.7 ± 3	140 ± 5
SDS	- 1.2 ± 0.7	- 1.5 ± 0.9	−1.2 ± 0.9
Age at peak velocity (yrs)	14.3 ± 1	14.2 ± 0.7	14.3 ± 1.2
Height at peak velocity (HPV)
cm	154.1 ± 4	153.6 ± 5	154 ± 6
SDS	- 1.3 ± 1	- 1.1 ± 0.8	−1.3 ± 1.1
Time interval between PGV and GH onset (mo)*^a	0.9 ± 0.6	1 ± 0.5	1 ± 0.7**
Growth velocity between PGV and GH onset
cm/yr	2 ± 1	2.3 ± 0.7	2.2 ± 0.8**
SDS	- 2.6 ± 1.4	- 3 ± 1.7	−2.8 ± 1.9**

We observed no significant differences between the groups. Values are expressed as mean ± SD.
^a*see Methods.
**mean age at GH onset in the GH treated adolescents was used to calculate corresponding values for time interval and growth velocity in the historical controls.

ISSN: 1687-9856