Proteomic analysis allows for early detection of potential markers of metabolic impairment in very young obese children

Table 4 Protein spot displaying intensity differences (p < 0.05) in pros-OB group after 2 SDS-BMI reduction

*Spot*	*Spot intensity after weight loss*	MS	MS	MS	*MS-MS*	*MS-MS*	*MS-MS*	*Identification*
*Spot*	*Significance level*	*Score/Cut.off*	*Matched fragments*	*Sequence coverage*	*Score/Cut-off*	*Matched fragments*	*Sequence coverage*	*Identification*
1704	Downregulated, p < 0.05	126/66	18	64	114/40	10(5)	37	*Alpha-1-Antitrypsin*
2201	Upregulated, p < 0.01	44/66	3	--	91/41	2(2)	12	*Apolipoprotein A1*
4801	Downregulated, p < 0.01	90/66	8	25	88/59	4(1)	12	*Alpha-1B-glycoprotein*
5103	Upregulated, p < 0.05	117/66	8	87	159/57	5(2)	79	*Transthyretin*
5503	Upregulated, p < 0.05	56/66	6	--	81/59	2(0)	4	*Haptoglobin*
7201	Upregulated, p < 0.01	106/66	16	66	76/59	3(2)	13	*Apolipoprotein A1*
7501	Upregulated, p < 0.05	55/66	4	--	86/59	2(2)	4	*Haptoglobin*
9101	Downregulated, p < 0.05	49/66	3	--	105/55	1(1)	4	*Haptoglobin*

The second column shows the direction of the change observed after weight loss. Abbreviations: MS Mass spectrometry, MS-MS Tandem mass spectrometry.

ISSN: 1687-9856