Table 1 Monitoring urea therapy.
From: Long-Term Outcomes in a Family with Nephrogenic Syndrome of Inappropriate Antidiuresis
| Age (months) | 3 (pre-urea therapy) | 4 | 6 (intercurrent illness) | 10 | 18 | 19 | 21 | 33 |
|---|---|---|---|---|---|---|---|---|
| Serum Na (135–145 mmol/L) | 124 | 139 | 118 | 136 | 140 | 137 | 138 | 139 |
| Serum urea (2.0–6.7 mmol/L) | 1.8 | 10.2 | 12.6 | 9.9 | 9.4 | 6.1 | 5.1 | 3.1 |
| ADH (0.1–7.0 pmol/L) | 0.6 | — | — | — | — | — | — | 1.2 |
| Urea dose | 1.5 g/kg/day, 6 divided doses | 2 g/kg/day, 4 divided doses | 2 g/kg/day, 4 divided doses | 1.9 g/kg/day, 4 divided doses | 1.2 g/kg/day, Weaning doses | Ceased | Nil | Nil |
| Fluid restriction | 70 mL/kg/day | 50 mL/kg/day | 50 mL/kg/day | 65 mL/kg/day (650 mL/day) | 80 mL/kg/day (1000 mL/day) | 80 mL/kg/day (1000 mL/day) | 90 mL/kg/day (1200 mL/day) | 75 mL/kg/day (1200 mL/day), increased to 94 mL/kg/day (1500 mL/day) |